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    The risk of osteoporosis and fracture influences the selection of adjuvant endocrine therapy. We analyzed bone mineral density (BMD) in Swiss patients of the Breast International Group (BIG) 1-98 trial [treatment arms: A, tamoxifen (T) for 5 years; B, letrozole (L) for 5 years; C, 2 years of T followed by 3 years of L; D, 2 years of L followed by 3 years of T]. Dual-energy X-ray absorptiometry (DXA) results were retrospectively collected. Repeated measures models using covariance structures allowing for different times between DXA were used to estimate changes in BMD. Prospectively defined covariates were considered as fixed effects in the multivariable models. Two hundred and sixty-one of 546 patients had one or more DXA with 577 lumbar and 550 hip measurements. Weight, height, prior hormone replacement therapy, and hysterectomy were positively correlated with BMD; the correlation was negative for letrozole arms (B/C/D versus A), known osteoporosis, time on trial, age, chemotherapy, and smoking. Treatment did not influence the occurrence of osteoporosis ( Aromatase inhibitors (AIs) are currently part of the standard endocrine therapy in postmenopausal women with early-stage endocrine-sensitive breast cancer [1]. Tamoxifen - Bone Density - Click to Cure Cancer Breast cancer & bone health Jean Hailes Prevention of bone loss after withdrawal of tamoxifen - NCBI - NIH
     
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