Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Prescribed for Depression, Panic Disorder, Major Depressive Disorder, Social Anxiety Disorder, Obsessive Compulsive Disorder, Premenstrual Dysphoric Disorder, Postpartum Depression, Post Traumatic Stress Disorder. May also be prescribed off label for Anxiety and Stress, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Trichotillomania, Transverse Myelitis, Somatoform Pain Disorder, Persistent Depressive Disorder, Generalized Anxiety Disorder, Dysautonomia, Dissociative Identity Disorder, Vulvodynia. " Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Prescribed for Depression, Panic Disorder, Major Depressive Disorder, Social Anxiety Disorder,... more Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Best wishes I'm a 31 year old Male who has had challenges with depression and anxiety throughout my life. Prescribed for Depression, Panic Disorder, Major Depressive Disorder, Social Anxiety Disorder, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder. The cons are it made me not very motivated, felt kind of numb to strong feelings. I wouldn’t take it again for years bc it blocked my clear perspective. Things that really help but can’t completely replace anti dep is fish oil, vit d, exercise, sunlight, folate like spinach , lentils really good. I have been on several different meds in my past, including lexapro, paxil, effexor, wellbutrin, prozac, zoloft, and some others as well. I am in Australia, and recently there has been a supply problem from Pfizer to Chemists. I have in the past been given a generic brand of Sertraline instead of Zoloft, and it didn't take long for me to find out that taking a generic brand was not for me. The generic brand didn't seem to be effective for me at all, and I definitely felt terrible. Since then I have insisted on Zoloft and would not accept a generic brand which would have cost less. Generic Venlafaxine has no time release properties, but there is now a Generic Extended Release formula of Venlafaxine now on the market. I know many people still on it and they report that they had a much better response to the name brand Effexor XR than with the Geneic Effexor XR. If it were me and I could afford it, I would go with the name brand. You only have to see your psychiatrist once or twice a year if you're not making changes to your meds and since most meds we take are generic, they don't cost very much. 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