Zoloft and grapefruit

Discussion in 'Canada Meds' started by Ervin, 06-Sep-2019.

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    Zoloft and grapefruit


    Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, panic disorder, and obsessive-compulsive disorder (OCD). Sertraline works by affecting the balance of chemicals in the brain. Specifically, it increases the level of a neurotransmitter called serotonin in the brain. Increased serotonin levels can help improve mood, reduce panic attacks, and treat OCD. Although improvements may occur earlier, the full response to the medication may not appear until after 4 weeks of treatment or longer. This medication may be available under multiple brand names and/or in several different forms. By Mike Mc Evoy Generic Name: Sertraline (multiple manufacturers) Common Brand Name: Zoloft (Pfizer Labs – U. S.) Popularity: 22nd most commonly prescribed drug between 2002 – 2007 (U. S.) Class: Antidepressant, SSRI (selective serotonin reuptake inhibitor)Treatment Uses – Treatment of major depressive disorder (MDD) in adults, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder. Sertraline has also been used effectively in treatment of aggressive behavior and dysthymia (a depressive disorder of less severity and longer duration than MDD). Sertraline has been helpful in treatment of alcoholism, Alzheimer’s disease, some pain syndromes, low blood pressure associated with hemodialysis, dyspnea associated with COPD, post-stroke emotional lability, and treatment of premature ejaculation. Investigational uses (under study) of sertraline include eating disorders, impulse control disorders, generalized anxiety disorder (GAD), and treatment of mild agitation associated with dementia in nonpsychotic patients. Sertraline has not been helpful in treating schizophrenia or eating disorders. Food and Drug Administration followed suit, but later admitted increasing skepticism about links between antidepressants and suicide risk in children and teens.

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    You should avoid drinking grapefruit juice while taking sertraline, as this may affect the level of sertraline in your blood and could increase the. Zoloft is a prescription anti-depressant, and people frequently wonder how it might interact withThis is similar to what happens when you combine antidepressants and grapefruit, which doctors advise. Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally.

    Grapefruit juice is an inhibitor of cytochrome P-450 3A4 (CYP3A4). This study was designed to assess the in vitro and in vivo effects of grapefruit juice on sertraline metabolism. The in vitro assay involved analysis of sertraline metabolism by CYP3A4 using CYP3A4-expressed human beta-lymphoblast microsomes. The in vivo study involved high-performance liquid chromatographic analysis of serum trough levels of sertraline and desmethylsertraline in 5 patients who had been taking their usual dose of sertraline for ≥6 weeks, followed by concurrent use of sertraline with grapefruit juice for 1 week. The in vitro assay demonstrated that grapefruit juice inhibited the formation of desmethylsertraline in a dose-dependent manner. In the in vivo study, mean serum sertraline levels were determined in 5 patients with a history of depression (4 males and 1 female). The mean age of the patients was 68.6 years, their mean weight was 69.6 kg, and their mean sertraline dosage was 55 mg/d. Sertraline hydrochloride is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It works by enhancing the activity of a neurotransmitter called serotonin in the brain. Neurotransmitters are natural body chemicals that act as chemical messengers between the nerve cells. Serotonin is a neurotransmitter known to be involved in regulating emotions, mood and behaviour, among other things. In depression and anxiety disorders there is a decreased amount of serotonin released from nerve cells in the brain. Sertraline works by stopping the serotonin that has been released from being reabsorbed back into the nerve cells in the brain. This helps to prolong its effects and over time this helps to lighten mood and relieve depression.

    Zoloft and grapefruit

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  7. Hi all, Im on 150mgs of Zoloft a day. I was eating at a restaurant and my dish had a small piece of grapefruit as the garnish probably around the size of a blueberry, so not even a full slice.

    • Accidentally Ate Grapefruit? - Zoloft/Lustral.
    • Grapefruit–drug interactions - Wikipedia.
    • Zoloft - Side Effects, Uses, Dosage, Overdose, Pregnancy..

    Grapefruit and grapefruit juice are healthful, providing enough vitamin C, potassium, dietary fiber, and otherGrapefruit can mean danger when combined with some popular drugs used for high blood. I just started back on Zoloft to prevent post partum depression after. Does anyone who is on or has been on Zoloft know if I can eat grapefruit? Zoloft sertraline is a prescription medication used to treat depression, anxiety, obsessive compulsive disorder andThis is because grapefruit and grapefruit juice can interfere with the first pass effect.

     
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