Tamoxifen and pregnancy

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  1. radrick Guest

    Tamoxifen and pregnancy


    I am a breast cancer survivor, five years come December 31, 2005. I am using Tamoxifen and have been for almost 5 years. I have done chemo and radiation and I had 17 lymph nodes removed, so praise to God, I am alive!!!! My question to anyone out there is this: My new husband and I are considering getting pregnant this year, before I am off of the Tamoxifen, but the only alternative that we have is for me to stop taking the medication earlier than December. Has anyone found any cases of this and that it was successful? My husband is a minister and we believe strongly that this is in God's hands and that we are to have a baby this year, but I am only human and I get a little afraid when I think of getting off the medication early to have a child and I think we have miscarried twice already. Any suggestions or places I can find research would be helpful. Women are conventionally advised to stop tamoxifen before attempting pregnancy. The risks of congenital malformations or late teratogenic manifestations in adulthood are unknown. Following an informed discussion about the uncertainties of tamoxifen exposure on pregnancy women should be offered the choice whether to continue or stop tamoxifen before attempting pregnancy. An unexpected pregnancy in a women taking tamoxifen could continue if the pregnant woman accepts the possibility of a teratogenic effect that tamoxifen could have on the fetus.

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    Pregnancy is characterized by growth and development, both of which are tightly linked to transcription and translation in strict time frames. Knowing the potent actions of tamoxifen and its metabolites, it is evident that there is a strong concern about the use of tamoxifen during pregnancy. Tamoxifen, unfortunately, is not a safe medication to take in pregnancy and should never be used. From studies looking at women who did mix tamoxifen and pregnancy, it's fairly clear that tamoxifen can increase the risk of congenital anomalies in the fetus it has teratogenic effects. These results suggest that a maternal exposure to tamoxifen during pregnancy acts as an estrogen in the fetal mammary gland and increases the susceptibility.

    For premenopausal patients with receptor-positive early breast cancer, administration of tamoxifen for 5 years constitutes the main adjuvant endocrine therapy. During pregnancy, tamoxifen and its metabolites interact with rapidly growing and developing embryonic or fetal tissues. Information about tamoxifen and pregnancy was gathered by searching Pub Med. In addition, we had access to the records of the pharmaceutical company Astra Zeneca. Because these observations are retrospective and other therapies and diagnostic measures are possible confounders, a causal relationship was not established between tamoxifen treatment and pregnancy outcome. The records from Astra Zeneca documented three live births with congenital anomalies and four live births without congenital anomalies related to tamoxifen treatment before pregnancy. Tamoxifen therapy during pregnancy resulted in 16 live births with congenital malformations and a total of 122 live births without malformations. Tricia19 wrote: I have been on tamoxifen for four months and am 5 weeks pregnant. Any information on personal experiences or studies would help me so much. My oncologist is advising termination but it seems to me that the studies are not conclusive that tamoxifen causes birth defects. Thank you for your help -Trish Jan 26, 2012 AM kk11 wrote: Hi Tricia - I don't have a personal experience with this, but just wanted to give you some support. I can understand how you may not want to terminate without conclusive evidence that it will cause birth defects. Jan 26, 2012 AM peggy_j wrote: What a difficult situation. I don't have experience with this but when I met with my new MO-referred GYNO late last year, we discussed birth control options while I'm on tamox. Have you asked your OB whether they could rule out the most serious potential defects through an NT scan? I asked what happens if I accidentally got pregnant and she said she would recommend terminating the pregnancy. Also, if you haven't already, I would definitely stop taking the Tamoxifen until you decide what to do. FWIW, I checked Pub Med and there is at least one study that shows the rates of possible congenital birth defects. I can only say that my fertility specialist recommended waiting 6 weeks after stopping Tamoxifen to try to get pregnant, so he definitely had his concerns, but I don't know if he would recommend termination. Listen to your doctors opinion, but remember they are human and don't always have the answers. Jan 26, 2012 PM - edited Jan 26, 2012 PM by rgiuff Research well the effects of tamoxifen on a fetus before you make your decision.

    Tamoxifen and pregnancy

    Tamoxifen for Infertility - University Reproductive Associates, Tamoxifen in Pregnancy Safety Concerns -

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  6. Women are conventionally advised to stop tamoxifen before attempting pregnancy. The risks of congenital malformations or late teratogenic manifestations in adulthood are unknown.

    • Tamoxifen and pregnancy - ResearchGate.
    • Maternal Exposure to Tamoxifen during Pregnancy Increases..
    • Tamoxifen Drug Interactions and Genetics -.

    Mar 28, 2018. Tamoxifen - Get up-to-date information on Tamoxifen side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about. Aug 6, 2018. Advice and warnings for the use of Tamoxifen during pregnancy. FDA Pregnancy Category D - Positive evidence of risk. Janine disease is that could be taken during pregnancy, cheap can detect a period blood clots in the unborn baby names. can tamoxifen cause ovarian cancer Et al, abozaripour m. Com candida yeast infection relief youtube sleep aid amazon 5 years drug used progesterone pregnancy is an ivf.

     
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