Azithromycin pediatric dose

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  1. Back Door Man Well-Known Member

    Azithromycin pediatric dose


    Zithromax (azithromycin) is an antibiotic commonly used in children to treat bacterial infections, such as ear and sinus infections. Often prescribed in pill form, it can also be delivered in a liquid formulation for children who don't like pills. Depending on the infection your child has, the treatment would typically last anywhere from one to five days. Though Zithromax is approved for use in children, its safety and effectiveness in kids under the age of six months haven't been established. The drug has been approved to treat the following pediatric conditions: Zithromax is often used off-label for other mild to moderate pediatric infections that are caused by susceptible bacteria including walking pneumonia, pertussis (whooping cough), and chronic bronchitis with a secondary bacterial infection. Increasing rates of azithromycin resistance mean that the drug is generally reserved for second-line use. For strep throat, penicillin is the preferred agent. Each 5 ml prepared suspension contains 204.8 mg azithromycin monohydrate equivalent to 200 mg azithromycin. Each 1 ml prepared suspension contains 40.96 mg azithromycin monohydrate equivalent to 40 mg azithromycin. Excipients with known effect: • Sucrose 3.70 g/ 5 ml • Aspartame (E951) 0.030 g/ 5 ml • Sodium 7.739 mg (0.336 mmol) /5 ml For the full list of excipients, see section 6.1. Azithromycin powder for oral suspension is indicated for the treatment of the following infections, when caused by micro-organisms sensitive to azithromycin (see section 4.4 and 5.1): - acute bacterial sinusitis (adequately diagnosed) - acute bacterial otitis media (adequately diagnosed) - pharyngitis, tonsillitis - acute exacerbation of chronic bronchitis (adequately diagnosed) - mild to moderately severe community acquired pneumonia - skin and soft tissue infections - uncomplicated Chlamydia trachomatis urethritis and cervicitis Considerations should be given to official guidance on the appropriate use of antibacterial agents. Adults In uncomplicated Chlamydia trachomatis urethritis and cervicitis, the dose is 1,000 mg in one single oral dose. For all other indications the dose is 1,500 mg, to be administered as 500 mg per day for three consecutive days. Alternatively the same total dose (1,500 mg) can also be given over a period of 5 days with 500 mg on the first day and then 250 mg on days 2 to 5.

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    Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Severe Interactions of azithromycin include pimozide; Azithromycin has serious interactions with at least 38 different drugs. Azithromycin has moderate interactions with at least 144 different drugs. Approximately 12% of an intravenously administered dose of azithromycin is, over a period of 3 days, excreted unchanged in the urine. Zithromax azithromycin is an antibiotic commonly used in children to treat bacterial infections, such as ear and sinus infections. Often prescribed in pill form, it can also be delivered in a liquid formulation for children who don't like pills.

    Community-acquired pneumonia: Oral: -Immediate-release: 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5 -Extended-release: 2 g orally once as a single dose Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy Comment: Extended-release formulations should be taken on an empty stomach. Uses: -Treatment of mild community acquired pneumonia due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae in patients appropriate for oral therapy -Treatment of community-acquired pneumonia due to C pneumoniae, H influenzae, Legionella pneumophila, Moraxella catarrhalis, M pneumoniae, or S pneumoniae in patients who require initial IV therapy Community-acquired pneumonia: Oral: -Immediate-release: 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5 -Extended-release: 2 g orally once as a single dose Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy Comment: Extended-release formulations should be taken on an empty stomach. Uses: -Treatment of mild community acquired pneumonia due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae in patients appropriate for oral therapy -Treatment of community-acquired pneumonia due to C pneumoniae, H influenzae, Legionella pneumophila, Moraxella catarrhalis, M pneumoniae, or S pneumoniae in patients who require initial IV therapy Community-acquired pneumonia: Oral: -Immediate-release: 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5 -Extended-release: 2 g orally once as a single dose Parenteral: 500 mg IV once a day as a single dose for at least 2 days, followed by 500 mg (immediate-release formulation) orally to complete a 7- to 10-day course of therapy Comment: Extended-release formulations should be taken on an empty stomach. Uses: -Treatment of mild community acquired pneumonia due to Chlamydophila pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus pneumoniae in patients appropriate for oral therapy -Treatment of community-acquired pneumonia due to C pneumoniae, H influenzae, Legionella pneumophila, Moraxella catarrhalis, M pneumoniae, or S pneumoniae in patients who require initial IV therapy Immediate-release: 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5 Use: Treatment of pharyngitis/tonsillitis caused by Streptococcus pyogenes as an alternative to first-line therapy in patients who cannot use first-line therapy IDSA Recommendations: Immediate-release: Individuals with penicillin allergy: 12 mg/kg orally once a day -Maximum dose: 500 mg/day -Duration of therapy: 5 days Use: Treatment of Group A streptococcal pharyngitis Immediate-release: 500 mg orally once a day for 3 days Extended-release: 2 g orally once as a single dose Comment: Extended-release formulations should be taken on an empty stomach. Use: Treatment of mild to moderate acute bacterial sinusitis due to H influenzae, M catarrhalis, or S pneumoniae Immediate-release: 500 mg orally as a single dose on day 1, followed by 250 mg orally once a day on days 2 to 5 Use: Treatment of mild to moderate uncomplicated skin and skin structure infections due to Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus agalactiae IDSA and NIH Recommendations: Immediate-release: Patients greater than 45 kg: 500 mg orally on day 1, then 250 mg orally once a day on days 2 through 5 Patients less than 45 kg: 10 mg/kg orally on day 1, then 5 mg/kg orally once a day for 4 additional days Alternative therapy for Bartonella infections (not endocarditis or central nervous system infections): 500 mg orally once a day for at least 3 months Uses: -Treatment of bacillary angiomatosis and cat scratch disease -Alternative therapy for Bartonella infections Gonococcal urethritis and cervicitis: Immediate-release: 2 g orally once Use: Treatment of mild to moderate urethritis and cervicitis due to Neisseria gonorrhoeae US Centers for Disease Control and Prevention (CDC) Recommendations: Immediate-release: -Recommended regimen: 1 g orally once as a single dose plus ceftriaxone -Alternative regimen: 1 g orally once as a single dose plus cefixime Comments: -The alternative regimen may be used for uncomplicated infections if ceftriaxone is unavailable. -Arthritis and arthritis-dermatitis syndrome may be treated with 1 g orally once plus cefotaxime OR ceftizoxime. Uses: -Uncomplicated gonococcal infections of the pharynx, cervix, urethra, and rectum -Treatment of gonococcal conjunctivitis -Treatment of arthritis and arthritis-dermatitis syndrome caused by disseminated gonococcal infection -Treatment of gonococcal meningitis and endocarditis Non-gonococcal urethritis and cervicitis: -Immediate-release: 1 g orally once Comment: A 1 g oral dose given once a week for 3 weeks may be effective in the treatment of lymphogranuloma venereum due to Chlamydia trachomatis. 500 mg PO once, then 250 mg once daily for 4 days 2 g extended release suspension PO once 500 mg IV as single dose for at least 2 days; follow with oral therapy with single dose of 500 mg to complete 7-10 days course of therapy Infection of pharynx, cervix, urethra, or rectum: Ceftriaxone 250 mg IM once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days CDC STD guidelines: MMWR Recomm Rep. June 5, 20(RR3);1-137 Agitation Allergic reaction Anemia Anorexia Candidiasis Chest pain Conjunctivitis Constipation Dermatitis (fungal) Dizziness Eczema Edema Enteritis Facial edema Fatigue Gastritis Headache Hyperkinesia Hypotension Increased cough Insomnia Leukopenia Malaise Melena Mucositis Nervousness Oral candidiasis Pain Palpitations Pharyngitis Pleural effusion Pruritus Pseudomembranous colitis Rash Rhinitis Seizures Somnolence Urticaria Vertigo Anaphylaxis Angioedema Anorexia Bronchospasm Constipation Dermatologic reactions Dyspepsia Elevated liver enzymes Erythema multiforme Flatulence Oral candidiasis Pancreatitis Pseudomembranous colitis Pyloric stenosis, rare reports of tongue discoloration Stevens-Johnson syndrome Torsades de pointes Toxic epidermal necrolysis Vomiting/diarrhea, rarely resulting in dehydration Neutropenia Elevated bilirubin, AST, ALT, BUN, creatinine Alterations in potassium Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Use with caution in abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death; discontinue azithromycin immediately if signs and symptoms of hepatitis occur Injection-site reactions can occur with IV route In treatment of gonorrhea or syphilis, perform susceptibility culture tests before initiating azithromycin therapy; may mask or delay symptoms of incubating gonorrhea or syphilis. Bacterial or fungal superinfection may result from prolonged use Prolonged QT interval: Cases of torsades de pointes have been reported during postmarketing surveillance; use with caution in patients with known QT prolongation, history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failure; also use with caution if coadministering with drugs that prolong QT interval or proarrhythmic conditions (eg, hypokalemia, hypomagnesemia); elderly patients may be more susceptible to drug-associated effects on QT interval Pneumonia: PO azithromycin is safe and effective only for community-acquired pneumonia (CAP) due to C pneumoniae, H influenzae, M pneumoniae, or S pneumoniae Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) reported; despite successful symptomatic treatment of allergic symptoms, when symptomatic therapy was discontinued, allergic symptoms recurred soon thereafter in some patients without further azithromycin exposure; if allergic reaction occurs, the drug should be discontinued and appropriate therapy instituted; physicians should be aware that allergic symptoms may reappear when symptomatic therapy discontinued Endocarditis prophylaxis: Indicated only for high-risk patients, per current AHA guidelines Use caution in renal impairment (Cr Cl Because of the low levels of azithromycin in breastmilk and use in infants in higher doses, it would not be expected to cause adverse effects in breastfed infants (Lact Med; https://nih.gov/newtoxnet/lactmed.htm) Binds to 50S ribosomal subunit of susceptible microorganisms and blocks dissociation of peptidyl t RNA from ribosomes, causing RNA-dependent protein synthesis to arrest; does not affect nucleic acid synthesis Concentrates in phagocytes and fibroblasts, as demonstrated by in vitro incubation techniques; in vivo studies suggest that concentration in phagocytes may contribute to drug distribution to inflamed tissues Y-site: Amikacin, aztreonam, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, clindamycin, droperidol, famotidine, fentanyl, furosemide, gentamicin, imipenem, cilastatin, ketorolac, levofloxacin, morphine, piperacillin-tazobactam, ondansetron(? ), potassium chloride, ticarcillin-clavulanate, tobramycin The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

    Azithromycin pediatric dose

    Zithromax Dosage Guide -, Azithromycin 200mg/5ml Powder for Oral Suspension - Summary of.

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  6. The dose for the treatment of pharyngitis caused by Streptococcus pyogenes is an exception in the treatment of pharyngitis caused by Streptococcus pyogenes Azithromycin has proved to be effective when it is administered to children as a single dose of 10 mg/kg or 20 mg/kg for 3 days with a maximum daily dose of 500 mg.

    • Azithromycin 200mg/5ml Powder for Oral Suspension.
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    Detailed Azithromycin dosage information for adults and children. Includes dosages for Bacterial Infection, Sinusitis, Bronchitis and more; plus renal, liver and dialysis adjustments. Here is what you need to know about Zithromax azithromycin, an antibiotic used to treat ear infections, strep throat, sinusitis, and pneumonia in kids. Pediatric Dosage Calculator. Choose a Medicine Pounds/Kilograms Calculator Weight in Pounds. Kilograms/Pounds Calculator. Weight in Kilograms. Fluid Calculator.

     
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    24 hours after lesion onset) Suppressive therapy (immunocompetent patients): 1 g/day PO Suppressive therapy (immunocompetent patients with ≤9 recurrences annually): 500 mg/day PO; transmission reduction for source partner, 500 mg/day PO Suppressive therapy (HIV-infected patients): 500 mg PO q12hr Thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) reported in patients with advanced HIV disease and in allogenic bone marrow transplant and renal transplant recipients Acute renal failure (ARF) may occur, especially in elderly patients or those with underlying renal impairment receiving higher than recommended doses; use with caution in patients with renal impairment, the elderly, and/or patients receiving nephrotoxic drugs Treatment should begin with the earliest symptom (tingling, burning, itching) in cold sores; for genital herpes, it should begin at the first signs and symptoms (within 72 hours of onset of first diagnosis or 24 hours of onset of recurrent episodes); for herpes zoster, it should begin within 72 hours of onset of rash; for chicken pox, it should begin with the earliest sign or symptom Central nervous system (CNS) effects may occur (eg, agitation, hallucinations, confusion, encephalopathy); risk of CNS adverse effects is higher in elderly patients Adequately hydrate patient; decreased precipitation in renal tubules may occur Metabolized by liver; valacyclovir is rapidly and nearly completely converted to acyclovir and L-valine via first-pass effect; acyclovir is hepatically metabolized to a very small extent by aldehyde oxidase and by alcohol and aldehyde dehydrogenase (inactive metabolites) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Discount Valaciclovir tabs 500mgpi Affordable. PRODUCT INFORMATION - Valacyclovir An overview - UpToDate
     
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