Propranolol toxicity

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  1. alien51 New Member

    Propranolol toxicity


    Beta-blocker overdose may result in intractable cardiovascular collapse despite conventional antidotal treatments. High dose insulin/glucose (ING), and more recently intravenous lipid emulsion (ILE), have been proposed as potentially beneficial therapies in beta blocker intoxication. We compare efficacy of the novel antidotes ING, with ILE, in a rabbit model of combined enteric/intravenous propranolol toxicity. Sedated, mechanically ventilated and invasively monitored New Zealand White rabbits underwent mini-laparotomy and enterostomy formation with 40 mg/kg propranolol instilled into the proximal small bowel. At 30 minutes propranolol infusion was commenced at 4 mg/kg/hr and continued to a target mean arterial pressure (MAP) of 50% baseline MAP. Animals were resuscitated with insulin at 3 U/kg plus 0.5 g/kg glucose (ING group), or 10 m L/kg 20% Intralipid (ILE group). In this study, the degradation of propranolol (PRO) by UV/persulfate process was systematically investigated. Direct photolysis of PRO was limited due to its low quantum yield, while the PRO degradation efficiency can be greatly promoted by the combination of persulfate and UV irradiation. Radical scavenging tests showed that both SOand OH contributed to the removal of PRO, with SOplaying a more important role. The degradation rate of PRO was improved by increasing the persulfate dose and initial solution p H consistent with pseudo-first-order reaction kinetics. The effects of common water constituents were species dependent. By contrast, NOand HA were found to inhibit PRO degradation. A total of nine degradation products were identified by LC/MS/MS, which mainly derived from the ring-opening attack on the naphthalene group or oxidation of the amino moiety by SOand OH. Finally, the toxicity of the reaction mixtures was also assessed using luminescent bacteria Vibrio fischeri, and the results indicated that UV/persulfate is capable of controlling the toxicity of PRO degradation.

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    Complications following beta blocker overdose are related to excessive beta adrenergic. Cardiovascular collapse and propranolol overdose. Propranolol hydrochloride further propranolol is a beta β-adrenergic blocking agent synthesized in 1964. It is currently used in medicine for the treatment of hypertension, arrhythmias, angina pectoris, myocardial infarction, open-angle glaucoma, migraine etc. 2, 3. Human toxicity The overdoses of propranolol can be toxic and even fatal. Coingestion with Calcium Channel Blockers, Tricyclic Antidepressants, and Antipsychotics increases mortality. Agents with membrane-stabilizing activity are especially lethal as they prolong QT, leading to dysrhythmias. Propranolol. Sotalol.

    While once a first-line treatment for hypertension, the role for beta blockers was downgraded in June 2006 in the United Kingdom to fourth-line, as they do not perform as well as other drugs, particularly in the elderly, and evidence is increasing that the most frequently used beta blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes. Propranolol is not recommended for the treatment of hypertension by the Eighth Joint National Committee (JNC 8) because a higher rate of the primary composite outcome of cardiovascular death, myocardial infarction, or stroke compared to an angiotensin receptor blocker was noted in one study. Propranolol works to inhibit the actions of norepinephrine, a neurotransmitter that enhances memory consolidation. In one small study individuals given propranolol immediately after trauma experienced fewer stress-related symptoms and lower rates of PTSD than respective control groups who did not receive the drug. Due to the fact that memories and their emotional content are reconsolidated in the hours after they are recalled/re-experienced, propranolol can also diminish the emotional impact of already formed memories; for this reason, it is also being studied in the treatment of specific phobias, such as arachnophobia, dental fear, and social phobia. Ethical and legal questions have been raised surrounding the use of propranolol-based medications for use as a "memory damper", including: altering memory-recalled evidence during an investigation, modifying behavioral response to past (albeit traumatic) experiences, the regulation of these drugs, and others. However, Hall and Carter have argued that many such objections are "based on wildly exaggerated and unrealistic scenarios that ignore the limited action of propranolol in affecting memory, underplay the debilitating impact that PTSD has on those who suffer from it, and fail to acknowledge the extent to which drugs like alcohol are already used for this purpose." Propranolol may be used to treat severe infantile hemangiomas (IHs). Beta blocker medications competitively antagonise the effects of catecholamines at the beta receptor decreasing inotropy and chronotropy. They are commonly prescribed in the management of cardiovascular disease, including heart failure, hypertension, ischaemic heart disease, tachyarrhythmia. Furthermore they are used to treat migraine, hyperthyroidism and benign tremor. They are uncommonly taken in overdose and can lead to significant morbidity. Toxicokinetics: The kinetics of beta blockers depend on their lipophilicity. Propranolol has the highest lipid solubility, while atenolol has the highest water solubility. High lipid solubility allows propranolol to rapidly cross the blood brain barrier and can result in neurotoxicity.

    Propranolol toxicity

    Massive Propranolol Overdose - Life in the Fastlane Medical, Propranolol hydrochloride Synonym Inderal - ACuteTox

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  5. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, whereas 50 mg/L metoprolol did not.

    • Toxicity and Enantiospecific Differences of Two.
    • Beta-blocker toxicity - WikEM.
    • Drug Toxicity Reduced Through New Liquid Salt Formula..

    A 27-year old female weighing 60kg presents to ED approximately one hour after swallowing 70 x 40mg propranolol tablets = 2.8 grams with. High dose insulin resulted in greater rate pressure product compared with lipid emulsion in this rabbit model of severe enteric/intravenous propranolol toxicity. Sinus bradycardia ± 1st degree AV block and interventricular conduction delay are most common dysrhythmia.2 QRS widening can occur in propranolol toxicity.

     
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