Tamoxifen side effects breast cancer

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  1. sbitseo XenForo Moderator

    Tamoxifen side effects breast cancer


    Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted. Tamoxifen is only prescribed to patients whose cancer has receptors within the cell that bind to oestrogen, according to Breast Cancer Care. The benefits of hormone therapy on people whose cancers do not have receptors is less clear – however, very few breast cancers fall into this category. Tamoxifen costs just 6p a day and can cut the chance of the disease by a third. In April, a study suggested that just one in seven women eligible to take the cheap breast cancer prevention pill are doing so. Experts estimate about 500,000 higher-risk women - those with a family history of the disease or a faulty gene - could benefit from the drug. But a survey of 258 by the University of Leeds found only 14.7 per cent were taking tamoxifen. Many believed cancer was "down to fate", while others said they did not want to take medication while they were well.

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    These are some of the many side-effects of Tamoxifen. I have had 2 bouts of breast cancer in the past 8 years. I switched the other way around. Tamoxifen is a hormone therapy drug used to treat ER+ breast cancer in pre- and post-menopausal women. Learn about how tamoxifen works and its side effects at Breast Cancer Care. In general, tamoxifen for five years reduces the probability of breast cancer recurrence by almost 50 percent, while risks of serious side effects are at around 1 percent or less,” he explained.

    9lives70 wrote: as I get ready to likely take this drug I am curious the worst side effects many of you have had with it...( especially those of you that are pre menopausal)In addition to the worst I would like to know the other SE's that were not horrendous but still not great :-) Thanks for sharing! Mar 21, 2017 PM warriorinpink94 wrote: For me the worst side effect has been the hot flashes. But if it helps to prevent more cancer I can take it. Mar 21, 2017 PM annoyingboob wrote: I haven't had any hot flashes, but some leg aches when I first started which seem to be going away. fingers be curious to hear if anyone got dvt or stroke and what underlying health issues were if any? I know you are worried about it but if you are at this point in your treatment you have already been through the worst. a bit of insomnia, but I swapped to taking it in the am, so hope that takes care of that. Mar 21, 2017 PM Lovinggrouches wrote: I've taken it since July of last year. The meds I have to take to counter effects of one med, not counting vitamin d, calcium and magnesium. Mar 22, 2017 PM Partyoffive wrote: hi I know I'm at a different stage then you but I wanted to tell you that I've been on tamoxifen for the past 31/2 years and have no terrible side effects. I have hot flashes, insomnia, depression, hair started falling out but is better now. Some hot flashes and leg cramps but I feel great and don't let it interfere with my life. It's been very tolerable for me and I wish you luck. Hugs Mar 23, 2017 PM Marcasey wrote: I've had hair loss, leg cramps, hot flashes , depression and fatique with tamoxifen. Kristi Mar 22, 2017 PM Lucy55 wrote: I take tamoxifen and have been very lucky and have no side effects ( that I know of ! I was scared to start taking it because I have trouble taking most other medications .it has been fine . At this point, I'm debating whether to come off it in order to start living again. Tamoxifen has rarely caused very serious (possibly fatal) strokes, blood clots in the lungs/legs, and cancer of the uterus. If you are taking tamoxifen to reduce the risk of breast cancer, or if your cancer is limited to the milk ducts (ductal carcinoma in situ-DCIS), then discuss the benefits and risks of taking this medication with your doctor. However, if you are taking tamoxifen to treat breast cancer, then the benefits of taking tamoxifen are greater than the risks of side effects. Get medical help right away if you develop symptoms of a stroke or blood clots in the lungs/legs, such as weakness on one side of the body, slurred speech, sudden vision changes, confusion, shortness of breath, chest pain, or calf pain/swelling. Tell your doctor right away if you develop symptoms of cancer of the uterus, such as unusual changes in your monthly period (e.g., amount or timing of bleeding), unusual vaginal discharge, or pain/pressure below your "belly button" (navel). Show More Tamoxifen is used to treat breast cancer. It is also used to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer.

    Tamoxifen side effects breast cancer

    Tamoxifen for Reducing Breast Cancer Recurrence, Tamoxifen Breast Cancer Care

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  5. Tamoxifen works by blocking/stopping the effects of estrogen in a person’s breast tissue. This is because hormone-receptor-positive breast cancer feeds on hormones like estrogen or progesterone to grow.

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    Breast Cancer Discussion Forums - Access the shared knowledge of thousands of people affected by breast cancer Tamoxifen is used to treat breast cancer, womb cancer and sometimes other cancers and conditions. It can be given as tablets or syrup that you can take at home. Its side effects can include hot flushes and sweats, changes to periods and tiredness. Tamoxifen is the most prescribed drug in the world for people with hormone receptor positive breast cancer, purportedly for the ability of this drug to stave off recurrences of breast cancer. Yet tamoxifen has been implicated in many potentially serious side effects − including cancer in the opposite breast.

     
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