Tamoxifen vs exemestane

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  1. erfilov Well-Known Member

    Tamoxifen vs exemestane


    uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website. Eine fünfjährige Tamoxifen-Einnahme gilt bislang als Standard in der adjuvanten Therapie des Estrogen-Rezeptor-positiven postmenopausalen Mammakarzinoms. In der Intergroup-Exemestan-Studie mit 4742 Patientinnen erhöhte ein Wechsel von Tamoxifen auf den Aromatasehemmer Exemestan nach zwei bis drei Jahren das krankheitsfreie Überleben innerhalb der nächsten drei Jahre. Standard in der adjuvanten (postoperativen) Behandlung Estrogen-Rezeptor-positiver Mammakarzinome ist eine fünfjährige Tamoxifen-Gabe. Sie senkt das Rezidivrisiko um fast die Hälfte und die Letalität um ein Viertel. Allerdings steigt mit der Dauer der Tamoxifen-Therapie das Risiko für thromboembolische Erkrankungen und Endometriumkarzinome. Außerdem kann der Tumor im Laufe der Behandlung – häufig schon nach 12 bis 18 Monaten – resistent gegenüber Tamoxifen werden, so dass Rezidive entstehen. Bei einem Brustkrebsrezidiv unter Tamoxifen sind andere Hormontherapien, wie Aromatasehemmer, häufig noch wirksam.

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    Compare Aromasin vs Tamoxifen head-to-head for uses, ratings, cost, side effects, interactions and more. Aromasin rated 5.3/10 vs Tamoxifen rated 6.3/10 in overall. A prior report at a median follow-up of 5 years showed no difference between exemestane vs sequential tamoxifen and exemestane in. OBJECTIVES Compare the efficacy and tolerability of adjuvant exemestane versus adjuvant tamoxifen in postmenopausal women with early breast cancer.

    The 10-year follow-up of the phase III TEAM trial has shown that exemestane alone and sequential tamoxifen/exemestane provide similar outcomes as adjuvant endocrine therapy in postmenopausal women with hormone receptor–positive early breast cancer. A prior report at a median follow-up of 5 years showed no difference between exemestane vs sequential tamoxifen and exemestane in disease-free survival. Study Details In the open-label trial, patients were randomized to 5 years of exemestane at 25 mg once daily or tamoxifen at 20 mg once a day for 2.5 to 3.0 years followed by exemestane for a total of 5 years. Of the original 9,776 patients, 6,120 (3,075 in exemestane group, 3,045 in the sequential group) were included in the current intention-to-treat analysis of disease-free survival. All patients from Japan (n = 184), France (n = 1,230), and the United States (n = 2,232) were excluded from the current analysis due to absence of long-term data. Patients included in the analysis were from the Netherlands, Germany, UK, Ireland, Belgium, and Luxembourg. Disease-Free Survival Median follow-up was 9.8 years. Disease-free survival at 10 years was 67% (95% confidence interval = 65%–69%) in the exemestane group vs 67% (95% CI = 65%–69%) in the sequential group (hazard ratio [HR] = 0.96, = .15). For premenopausal, hormone-sensitive breast cancer patients, the estrogen blocker tamoxifen is often prescribed after surgery to help prevent the cancer from returning. But new research data may change this longstanding practice since it found the aromatase inhibitor exemestane (trade name Aromasin) to be more effective this role. These findings came from a joint analysis of two phase III breast cancer clinical trials, called TEXT and SOFT, and were presented during the plenary session of the American Society of Clinical Oncology annual meeting. Reporting on the study, lead author Olivia Pagani, M. D., said that the exemestane group were 34 percent less likely than the tamoxifen group to develop a subsequent breast cancer."For years, tamoxifen has been the standard hormone therapy for preventing breast cancer recurrences in young women with hormone-sensitive disease. These results confirm that exemestane with ovarian function suppression constitutes a valid alternative," said Pagani, clinical director of the Breast Unit at the Oncology Institute of Southern Switzerland, in a press release. For this study, Pagani and her team looked at data from almost 4,700 women in both trials.

    Tamoxifen vs exemestane

    Adjuvant anastrozole versus exemestane versus letrozole, upfront or., Year Follow-up on Adjuvant Tamoxifen and Exemestane in.

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  6. Dutch postmenopausal early breast cancer patients were randomized between 5 years of exemestane, or tamoxifen 2.5–3 years.

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    The first part of the TEAM trial compares exemestane with tamoxifen directly, and as monotherapy after diagnosis, and it showed no difference. Adjuvant Anastrozole vs Exemestane. Outcomes were similar among patients who received 5 years of AI therapy and those who received 2 years of tamoxifen. Preliminary data from the open-label TEAM trial comparing exemestane with tamoxifen indicated in 2009 that exemestane 25 mg/day is also effective in the primary.

     
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