Sildenafil pulmonary

Discussion in 'Online Canadian Discount Pharmacy' started by anderver, 20-Aug-2019.

  1. znamenskiyd New Member

    Sildenafil pulmonary


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    Sildenafil is a phosphodiesterase type 5 inhibitor that has an expanding role in the treatment of pulmonary hypertension. Case series and small studies, as well. Original Article from The New England Journal of Medicine — Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension. Sildenafil thus increases cGMP within pulmonary vascular smooth-muscle cells, resulting in relaxation. In patients with pulmonary hypertension, this can.

    Madrid, Spain—The prescribing of sildenafil to treat residual hypertension in patients with valvular heart disease should raise a red flag for pharmacists. That warning came from late-breaking results of the SIOVAC trial that were presented at the European Society of Cardiology meeting in Barcelona, Spain. At a Hot Line LBCT Session at the ESC Congress, Hospital General Universitario Gregorio Marañon–led researchers reported that off-label use of the drug led to worse clinical outcomes, including twice the risk of hospitalization, compared with placebo.“Valvular disease is considered the next cardiac epidemic because of its strong association with age and the rapid aging of the population worldwide,” said principal investigator Javier Bermejo, MD, Ph D. “The only established treatment is repair or replacement of the valve surgically or percutaneously. But symptoms often remain or reappear in the long-term. Residual pulmonary hypertension is the most important risk factor for death and disability after successful correction of the valvular lesion.”Increased blood pressure in the pulmonary artery might persist after valve treatment, according to the study, which points out that sildenafil—which usually is used to treat erectile dysfunction—is frequently prescribed off-label in patients with retrograde pulmonary hypertension. Conducted in 17 public hospitals and coordinated by the Spanish Network Centre for Cardiovascular Research (CIBERCV), the SIOVAC trial looked at whether sildenafil can improve long-term outcomes in patients with residual pulmonary hypertension after correction of a valvular lesion. Initial dose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity Maintenance: 25 to 100 mg orally once a day, as needed, 1 hour prior to sexual activity Comments: This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity. Use: Treatment of erectile dysfunction Revatio (R): Oral: -Initial dose: 5 or 20 mg orally three times a day, 4 to 6 hours apart -Maximum dose: 20 mg orally three times a day Injection: -Initial dose: 2.5 or 10 mg IV bolus three times a day Comments: -No greater efficacy was achieved with oral doses higher than the maximum recommended dose. -A 10 mg injection dose is predicted to provide pharmacological effect equivalent to the 20 mg oral dose. Use: Treatment of PAH (WHO Group I) in adults to improve exercise ability and delay clinical worsening Initial dose: 25 mg orally once a day 1 hour prior to sexual activity Use: Treatment of erectile dysfunction Erectile dysfunction: -Mild to moderate renal dysfunction (Cr Cl 30 to less than 80 m L/min): No adjustment recommended. -Severe renal dysfunction (Cr Cl less than 30 m L/min): 25 mg orally once a day 1 hour prior to sexual activity Pulmonary Arterial Hypertension: Revatio (R): -No adjustment recommended. Erectile dysfunction: -Initial dose: 25 mg orally should be considered in patients with any degree of hepatic impairment Pulmonary Arterial Hypertension: Revatio (R): -Mild to moderate hepatic dysfunction (Child-Pugh Class A and B): No adjustment recommended. -Severe hepatic dysfunction (Child-Pugh Class C): Has not been studied Concomitant administration with alpha blockers: -Initial dose: 25 mg orally 1 hour prior to sexual activity -Patients should be stable on alpha blocker therapy prior initiating treatment with this drug.

    Sildenafil pulmonary

    Sildenafil pulmonary hypertension - PubMed - NCBI, Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension NEJM

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  7. Compare prices, print coupons and get savings tips for Sildenafil Generic Viagra and Revatio and other Pulmonary Hypertension and Erectile Dysfunction drugs at CVS.

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    Mar 2, 2009. Background. Sildenafil is a cyclic guanosine monophosphate-specific phosphodiesterase-5 inhibitor used for treating pulmonary hypertension. Pulmonary arterial hypertension PAH is a life-threatening disease of varied etiologies. Although PAH has no curative treatment, a greater understanding. Detailed Sildenafil dosage information for adults and the elderly. Includes dosages for Erectile Dysfunction and Pulmonary Hypertension; plus renal, liver and.

     
  8. Delico Well-Known Member

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