Valacyclovir vs acyclovir effectiveness

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  1. l-tochka Well-Known Member

    Valacyclovir vs acyclovir effectiveness


    Valacyclovir (Valtrex, marketed by Glaxo Smith Kline) and acyclovir (Zovirax, marketed by Sanofi-Aventis) are used mainly for treatment of genital herpes. Both are antiviral drugs and can be taken orally to shorten herpes symptoms or to prevent this infection from recurring in healthy individuals. Acyclovir pills had been in use from 1991 and enjoying the status of a first-of-its-kind antiviral drug for genital herpes treatment, until Valtrex was approved by the US Food and Drug Administration (FDA) 4 years later in 1995. The valacyclovir vs acyclovir debate started since then and it still remains a matter of research interest as to which drug you can use to cope with herpes better. Valacyclovir advantages Valacyclovir has a number of key advantages over other similar antiviral medications. Clinical trials have shown that this drug has greater effectiveness in dealing with the herpes simplex virus (HSV) or the varicella zoster virus (VZV), compared to acyclovir or other drugs. Another plus factor of Valtrex is that it is probably the only medicine that can reduce the risk of herpes transmission, given that safe sex methods are used. Valacyclovir exhibits better oral absorption and higher, more prolonged serum concentrations than oral acyclovir. The efficacy of valacyclovir and acyclovir on genital herpes simplex virus (HSV) shedding was assessed in a double-blind, 3-period crossover trial. Sixty-nine immunocompetent participants with genital HSV-2 received oral valacyclovir, acyclovir, and matching placebo in random order for 7-week periods. Participants provided daily genital mucosal swabs for HSV detection by viral culture and polymerase chain reaction (PCR). HSV was detected at least once in 62 (90%) participants by culture and in 68 (98%) by PCR. During placebo, the total HSV shedding rate was 15.4% of days by culture (PCR, 40.2%); the subclinical shedding rate was 6.6% by culture (PCR, 27.1%). Both antivirals were associated with lower HSV shedding by culture (relative risk [RR], 0.03 [95% confidence interval , 0.01–0.07] for valacyclovir and RR, 0.05 [95% CI, 0.03–0.10] for acyclovir) and PCR (RR, 0.18 [95% CI, 0.12–0.26] for valacyclovir and RR, 0.20 [95% CI, 0.15–0.28] for acyclovir), compared with placebo.

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    Jun 4, 2015. *Valacyclovir 500 mg once a day might be less effective than other valacyclovir or acyclovir dosing regimens in persons who have very frequent. ObjectiveTo compare valacyclovir hydrochloride with acyclovir in the treatment. Results Both drugs were significantly more effective than placebo in speeding. respectively; the hazards ratios for valacyclovir and acyclovir vs placebo were. Find user ratings and reviews for valacyclovir oral on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction

    Description Valtrex (Valacyclovir hcl), the valine ester of acyclovir, is an antiviral agent active against herpes viruses, varicella-zoster virus, Epstein-Barr virus and to a lesser extent cytomegalovirus. Valtrex is used to treat genital herpes, orofacial herpes (cold sores), and herpes zoster (shingles). It is effective and safe for long-term suppression of recurrent genital herpes. Suppressive therapy is appropriate when outbreaks are frequent, severe, or emotionally disturbing. Valtrex is proven to reduce the risk of transmission of genital herpes. Valacyclovir suppresses shedding of HSV-2 on genital mucosal surfaces and may prevent sexual transmission of HSV. Valtrex effectiveness In herpes zoster, valacyclovir is more effective than acyclovir and equally effective as famciclovir in shortening the length and severity of shingles-associated pain and postherpetic neuralgia. Prompt treatment with valacyclovir can abort impending outbreak of both cold sores or genital herpes. 1) I have the beginnings of a cold sore on the lip. For Valacyclovir and Valtrex the recommended dosage is 2000mg every 12 hours...total of 4000mg in 24 hours. I have 2000mg of Valtrex and 2000mg Valacyclovir from prior outbreaks. Or do I need to take the 4000mg total dose with the same drug? 2) I am getting cold sores on the lip up to 3 times a year. Each outbreak if not treated early is as severe as all the rest. There is no reason to worry that taking your vitamins and valacyclovir at the same time might interfer with the effectiveness of each other. Please do not worry about this as a possible cause of your recent recurrences. Is there any residual uncertainty due to my having taken valacyclovir (3 g/day for a week after the suspected outbreak; 1 g/day subsequently until now).

    Valacyclovir vs acyclovir effectiveness

    Which HSV-2 Antiviral Works Best? — Precision Vaccinations, A Randomized, Placebo-Controlled Comparison of Oral Valacyclovir.

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    Acyclovir vs Valacyclovir Acyclovir and Valaciclovir are two antiviral drugs. These two drugs belong to the same drug class. Because these two are in the same class. What would be the benefit to taking valacyclovir vs acyclovir? Asked by chintzia Updated 30 July 2013 Topics acyclovir, valacyclovir Jun 9, 2008. acyclovir, valacyclovir hydrochloride, or famciclovir and dosing regimen. Once-daily dosing schedules were less effective or provided no.

     
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