Tamoxifen uterine thickening

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  1. Nedovas Well-Known Member

    Tamoxifen uterine thickening


    Hi ladies I wrote a post a few weeks ago regarding my concerns of having some unwelcome symptoms due to tamoxifen, i.e bloating, left side abdominal pain. Over the last few weeks I have had firstly an ultrasound and internal ultrasound which showed uterus had thickened and a cyst on left ovary, so to follow up had an MRI last week and then a hysteroscopy yesterday and I've had blood works done, ca125 being one of them which is a tumour biomarker. So..MRI apparently shwed a 6cm cyst on ovary and a polyp in uterus. The gynae yesterday during hysteroscopy was fully expecting to find this polyp but couldn't, all she could seem to find was what she called a lot of scarring within the uterus/womb and said she couldn't understand why/how it was there, so she's taken biopsies and I should get results in a week. She said that she was concerned as my womb didn't look how she expected based on MRI results and was of the feeling it could be 'something a bit scarier', she later clarified poss endometrial cancer which is a risk, although apparently a low one of tamoxifen. I am completely freaked out now, had no bleeding ever whilst on tamoxifen, my periods stopped on chemo in oct 2015. So the thing that really made me go docs was left sided pain which is a cyst! I had a lumpectomy in April 2006; 8 rounds of chemo and 34 radiation treatments. I have not had a 'period' since August 2006 and I am now 42 this week. I went to have a uterine ultrasound to see if I am still fertile to have another child and my OBGYN noticed a thickening of my uterine lining at a 15 and some cyctlike things on the lining. Also, two cycts on the one ovary and she said that we should think positively that the ovary is 'active'. My breast cancer was a mucuous carsomina; stage 1c, well differentiated. I am scheduled to have a D&C on Friday and am so scare that is could be some form of cancer. My OBGYN just wants to be safe and ordered to have the D&C performed. Hi, Well, nothing can be said about the chances before the examination is done and the lab analysis reports come in. Tamoxifen is known to cause benign endometriosis as well as endometrial cancer - only investigatons will help to come to a definite diagnosis. If you want to go ahead and plan a pregnancy after your reports come in and hopefully they turn out ok, you should talk to your doctor/ oncologist and discontinue taking tamoxifen.

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    I had a D&C for a thicken endometrium. I had been off Tamoxifen as it failed and on Arimidex when I had my first episode of bleeding. I had many, many endometrium biopsy that were all negative. A real long story. I ended up with Endometrium hyperplasia with polyps. I also had uterine lining thickening on ultrasound -- it was actually 18mm, and had a biopsy. It came back normal -- proliferative endometrium is not necessarily thickening if you are premenopausal -- it is the phase of your cycle where it is supposed to thicken -- with tamoxifen it just thickens a little bit more. Consequently, a large number of women will be subjected to both the benefits and potential risks of long-term tamoxifen therapy. One of the most significant potential complications is the development of endometrial cancer. The estimated annual risk of endometrial cancer in tamoxifen-treated patients is approximately 2 per 1,000 women.

    Maeve wrote: Hi, Just been for a smear (PAP) test today and the nurse told me I had an unusually thickend lining on my cervix, I know that Tamox. can interfere with the uterus in different ways but just wondered if anyone experienced the same problem. I've been on tamoxifen for just over 18 months and would love to her from anyone who has had uterus problems as a result of tamoxifen. Many Thanks Feb 23, 2009 AM kuchagirl wrote: Hi, My endometrial lining thickened up considerably around 10 months after I started Tamoxifen, as seen on ultrasound. My gynecologist says there's nothing to worry about. Also, I've googled around for medical studies on Tamoxifen's impact on the endometrial lining, and it is normal for the endometrial lining to thicken and to stay thickened as long as the patient is on Tamoxifen. I did have one episode of spotting (which led to an ultrasound which showed the thickened lining), but have not had any spotting at all in 12 months. This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer The paragard iud is hormone free. It works by creating a toxic environment for sperm preventing fertilization. Because it is hormone free it has no real effect on the endometrial lining. It does not thin it out like Mirena (levonorgestrel) but also does not thicken it either. Read more See 1 more doctor answer Your gynecologist must discuss this with you as soon as possible. Read more Thickening of the endometrium during a normal menstrual cycle is due to estrogen prodcution by a follicle (which can appear as a cyst on ultrasound). There are many ways to determine if things are OK or not and the gynecologist will help you. There are some other cysts, like a granulosa cell tumor that also can make estrogen and thicken the endometrium. Polyps, fibroids and other conditions can also make the lining appear thicker on ultrasound. Read more It may be time for a hysterosalpingogram (HSG) or sono HSG to ensure there isn't another process occurring.

    Tamoxifen uterine thickening

    Endometrial Thickness in Post Menopausal, Breast Cancer Topic Tamoxifen & thickening of uterus lining

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  3. P.s ca125 came back well within normal range, I was under impression it was just for ovarian cancer but can detect other cancers within the body i.e uterine/endometrial. I started tamoxifen 2 years ago.

    • Update on Tamoxifen thickening uterus. -.
    • The Effect of Tamoxifen on the Endometrium Cancer Network.
    • OVARIAN CANCER Personal Stories.

    Tamoxifen and Uterine Cancer. ABSTRACT Tamoxifen, a nonsteroidal antiestrogen agent, is widely used as adjunctive therapy for women with breast cancer, and it has been approved by the U. S. Food and Drug Administration for adjuvant treatment of breast cancer, treatment of metastatic breast cancer, and reduction in breast cancer incidence in high-risk women. A Pap smear is a simple, quick, and essentially painless screening test procedure for cancer or precancer of the uterine cervix. Cells collected from a woman's cervix during a pelvic exam are spread on a microscope slide for examination.; The cells are evaluated for abnormalities, specifically for pre- cancerous and cancerous changes. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Fowler on endometrial lining thickening on tamoxifen Not thicken during menstruation.

     
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