Tamoxifen diabetes

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    Tamoxifen diabetes


    For estrogen-receptor positive breast cancer cases, tamoxifen has been the most important adjuvant hormonal therapy for the purpose of reducing recurrence rates and prolonging disease free survival. However, several side effects have been noticed, and fatty liver is one of the most common side effects among them. Since fatty liver is a common problem in the general population, we wanted to examine the effects of tamoxifen under pre-existing fatty liver conditions and evaluate the prevalence of tamoxifen-related impaired liver function. We recruited breast cancer cases at ages 20−70 years and divided them into tamoxifen or control groups. Personal information was collected, and fasting blood tests and abdominal ultrasound were performed. The changes of fatty liver degree between the initial and follow-up ultrasound were divided into five categories. Of the 406 enrolled participants, 266 were in the tamoxifen group and 140 were in the control group. Key clinical point: Prophylactic tamoxifen reduced breast cancers in vulnerable women, compared with placebo, but didn’t affect overall mortality. Major finding: Five years of tamoxifen treatment translated into a 30% decrease in the incidence of breast cancers among at-risk women, but there was no survival benefit at 20 years of follow-up. Data source: The IBIS-1 trial randomized more than 7,000 women to 5 years of either tamoxifen or placebo. Disclosures: The IBIS-I trial was supported by Cancer Research UK. Cuzick has received funding for other trials from Astra Zeneca and is a consultant for Astra Zeneca. The company also provided both the study drug and placebo. SAN ANTONIO – Five years of tamoxifen provided 20 years of breast cancer prevention to some at-risk women who took it prophylactically. However, their 20-year all-cause mortality was no different from those taking placebo (182 vs.

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    Nov 22, 2011. The findings do not mean tamoxifen is a direct cause of diabetes in this patient population, the study authors emphasized, but they said its use. Type 1 diabetes T1D results from the destruction of pancreatic β-cell through the β-cell specific autoimmune process. β-cell autoantigens, macrophages, dendritic cells DC, B lymphocytes, and T lymphocytes have been implicated in the pathogenesis of autoimmune diabetes. Tamoxifen is a. Sep 20, 2011. Tamoxifen may increase diabetes incidence through its estrogen‐inhibiting effects. This study assessed whether tamoxifen treatment in older.

    Lorraine Lipscombe, scientist at Women’s College Research Institute and endocrinologist, reports surprising findings about a commonly used breast cancer medication. Her team found that in older breast cancer survivors, tamoxifen is associated with a significantly increased risk of diabetes, even after adjustment for other risk factors. “Tamoxifen is an important treatment for estrogen-receptor breast cancer that has been shown to improve breast cancer survival,” says Lipscombe. “We found that diabetes was 24 per cent higher in women who were using tamoxifen treatment, not with previous tamoxifen users. “This suggests that although current tamoxifen therapy may increase the risk of diabetes in people who are susceptible, this risk does not continue after the medication is discontinued.” The researchers suspect that the underlying mechanisms may be related to tamoxifen’s estrogen-inhibiting effect. Evidence suggests that estrogen plays a role in regulating blood glucose levels, and indeed post-menopausal women, whose estrogen levels are naturally lower, have a higher prevalence of diabetes, weight gain, insulin resistance and metabolic syndrome. Furthermore, post-menopausal estrogen replacement therapy has been shown to reduce the incidence of diabetes. About 1.5 years after taking Tamoxifen, I had a slightly elevated fasting blood glucose on an annual visit with my primary doctor. She wasn't concerned, but I was and started monitoring my blood sugar. It's always higher (and above the recommended 126) when I eat simple carbs. I did a little research on the Internet and do read there is a connection between diabetes and Tamoxifen. Has anyone else had this experience, and what did you do about it? I walk to/from work total 4 miles daily but sit most of the day at a computer. I changed my diet to low carb (most of the time) and smaller portions. I'm 5'6" and in 2 years went from 132 to 120 with the exercise snd then the diet change so weight loss didn't improve anything.

    Tamoxifen diabetes

    Diabetes Risk Elevated in Breast Ca Survivors Treated with Hormone., Beneficial Effects of Tamoxifen Treatment in Type 1 Diabetes

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  4. Tamoxifen is an important treatment for estrogen-receptor breast cancer that has been shown to improve breast cancer survival,” says Lipscombe. “We found that diabetes was 24 per cent higher in women who were using tamoxifen treatment, not with previous tamoxifen users.

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    Dec 15, 2014. SAN ANTONIO – Five years of tamoxifen provided 20 years of breast cancer prevention to some at-risk women who took it prophylactically. Tamoxifen and diabetes. Chronic Illness Forums. I did a little research on the Internet and do read there is a connection between diabetes and Tamoxifen. Sep 6, 2018. For a long time, women who had been pre-menopausal at the time of diagnosis were prescribed tamoxifen for five years. Women who were.

     
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